Our Conference: International Conference on Human Nutrition and Functional Medicine

Our Journal: International Journal of Human Nutrition and Functional Medicine

Our Newsletter: Sign-up here so we can keep you up-to-date


2013 International Conference on

Human Nutrition and

Functional Medicine

Portland Oregon Convention Center September 25-29, 2013

PDF Overview and Schedule •  1-page Flyer  • Registration is now open

PDXvideo  •  MITOvideo  •  All videos


Target Audience:

  • Healthcare professionals: Medical (allopathic, osteopathic, naturopathic) physicians, chiropractic doctors, dieticians, nutritionists, graduate students, researchers, academicians/directors, other healthcare professionals; general public may also attend.

Educational Methods:

  • Didactic lecture, reading materials and peer-reviewed articles, slide presentations, interactive question-and-answer sessions, case reports and problem-based learning exercises.

Learning Objectives:

  • To describe and define recent important and consensus-approaching advances in basic science and clinical trials research related to topics of nutrition, molecular biology, and metabolism that are appropriate for translation into clinical practice.

  • To demonstrate and exemplify the actual clinical applications of new research and evidence so that physicians can apply this data to clinical practice and patient utilization and treatment compliance.

For more information about the speakers, schedule, and educational details, please see our PDF Overview and Tentative Schedule.


Accreditation for continuing medical education (CME) for medical doctors:

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council of Continuing Medical Education through the joint sponsorship of the University of Texas Medical Branch at Galveston and International College of Human Nutrition and Functional Medicine. The University of Texas Medical Branch at Galveston is accredited by the Accreditation Council of Continuing Medical Education to provide continuing medical education for physicians.

The University of Texas Medical Branch at Galveston designates this live activity for a maximum of 35.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Accreditation for continuing education for dieticians: Dannemiller is a Continuing Professional Education (CPE) Accredited Provider with the Commission on Dietetic Registration (CDR). Registered dieticians (RDs) and dietetic technicians, registered (DTRs) will receive [approximately 30-35] continuing professional education units (CPEUs) for completion of this material. Learning Level 2: Assumes that the participant has general knowledge of literature and professional practice in the area(s) covered. The focus of the activity is to enhance knowledge and application by the participant.


Accreditation for continuing education for chiropractors: University of Western States is recognized by the PACE program of the Federation of Chiropractic Licensing Boards and will provide at least 36 (thirty six) hours of continuing education. States approved by PACE: AK, ID, IN, IA, KS, MA, ME, MN, MT, NC, ND, NE, NM, NV, OH, OK, OR, SC, SD, UT, VT, Puerto Rico, Nova Scotia. CCE college sponsored programs are accepted for continuing education in CO, CT, DE, GA, IA, ID, IL, IN, MI, MS, MT, ND, NE, NM, OR, SC, UT, VA, VT, WA, WY, BC.


Oregon Board of Naturopathic Examiners has advised that ACCME PRA-1 CME is valid for naturopathic licensure renewal. NDs should check with their respective states.






PDF Overview and Tentative Schedule    Registration: NOW OPEN

Location: Oregon Convention Center

City: beautiful Portland, Oregon video1 video2 video3



Brief outline of topics by day:

  • Wednesday 9/25 • Preconference Introduction, Overview and Pharmacology included: 1) History and Direction of Functional Medicine: From Concept to New Branch of Science and Academic Discipline, 2) Functional Inflammology: Deciphering and Treating Disorders of Chronic Inflammation, 3) Integrative Pharmacology for Disorders of Chronic Pain and Inflammation:

    • Clinical Focus: Migraine, Fibromyalgia, Rheumatoid Arthritis, Psoriasis, and Osteoarthritis


  • Thursday 9/26: MindBody Medicine and Nutrition for the Brain:

    • Clinical Focus: Mood, Memory, Attention/ADHD, Alzheimer's and Parkinson's Diseases, Traumatic Brain Injury


  • Friday 9/27: Mitochondrial Nutrition, Obesity, Diabetes, and Cancer: From Meals to Molecules to Mitochondria to (Prevention of) Maladies and Malignancy

    • Clinical Focus: Migraine, Fibromyalgia, Diabetes and Insulin Resistance, Cardiovascular Disease and Cancer Prevention


  • Saturday and Sunday 9/28-29: The Optimal Daily Diet and Lifestyle: Meals, Molecules, and Mechanisms

    • Clinical Focus: Integrative Evidence-Based Prevention and Treatment of Common Health Problems such as Overweight, Insulin Resistance, Hypertension, Diabetes, Cardiovascular Disease







Conference Speakers:
  • Dr Jeffrey Bland, Scholarship Announcement, Personalized Lifestyle Medicine Instititute

  • Dr Alex Vasquez, International College of Human Nutrition and Functional Medicine

  • Dr Loren Cordain, Colorado State University

  • Dr Garth L. Nicolson, Professor Emeritus at the Institute for Molecular Medicine

  • Dr James OKeefe, Saint Luke's Health System

  • Dr Michael J. Gonzalez, University of Puerto Rico Medical School

  • Dr Deanna Minich, International College of Human Nutrition and Functional Medicine

  • Dr Matthew Hirschey, Duke University

  • Dr Lynda Frassetto, University of California, San Francisco

  • Dr David Haase, International College of Human Nutrition and Functional Medicine

  • Dr Kenneth Cintron, Ponce School of Medicine in Puerto Rico

  • Dr. Thomas O'Bryan, National University of Health Sciences

  • Pedro Bastos MA MS Ph.D. candidate in Medical Sciences at Lund University, Sweden, International College of Human Nutrition and Functional Medicine

  • Maelan Fontes MS Ph.D. candidate in Medical Sciences at Lund University, Sweden, International College of Human Nutrition and Functional Medicine


Jeffrey Bland Ph.D., F.A.C.N. including: scholarship announcement and award for Scholarship and Innovation; Functional Medicine: from concept to new graduate-level field of study and university-based scientific and academic discipline

  • Biographical sketch: In 1981, Jeffrey Bland was invited by two-time Nobel Laureate in Chemistry and Peace, Linus Pauling, to become the Director of Nutritional Supplement Analysis at the Linus Pauling Institute in Palo Alto, California. Currently based in Gig Harbor, Washington, Dr. Jeffrey Bland has been an internationally recognized leader in the nutritional medicine field for over 25 years. Dr. Bland founded HealthComm International, Inc. in 1984, and served as its Chief Executive Officer until a merger with its strategic partner, Metagenics, in 2000. Dr. Bland served as Chief Science Officer for Metagenics and President of MetaProteomics for 12 years. In 2012, Dr. Bland formed a nonprofit organization called the Personalized Lifestyle Medicine Institute (PLMI) based in Seattle, Washington. More information about the PLMI can be found at www.plminstitute.org. A nutritional biochemist and registered clinical laboratory director, Dr. Bland is a former professor of biochemistry at the University of Puget Sound, and a previous Director of Nutritional Research at the Linus Pauling Institute of Science and Medicine. He was the first member of the Board of Trustees of Bastyr University, the first federally accredited university in the United States offering graduate and undergraduate degrees in natural medicine, and contributed significantly to its founding and accreditation. With his wife, Susan Bland, MA, he founded the Institute for Functional Medicine, now a respected nonprofit organization. Throughout his long career, two activities have remained constant for Dr. Bland: production of his monthly audio publication, Functional Medicine Update (FMU), and an annual one-day seminar tour. Synthesis is the exclusive distributor of these educational products, as well as numerous other materials produced by Dr. Bland.

Alex Vasquez D.C., N.D., D.O., F.A.C.N.

  • Biographical sketch: Dr Vasquez graduated from University of Western States (Doctor of Chiropractic), Bastyr University (Doctor of Naturopathic Medicine), and University of North Texas Health Science Center (Doctor of Osteopathic Medicine) and has written approximately 100 articles, numerous audios and videos, and more than10 books. Dr Vasquez lectures to doctors and healthcare professionals internationally and founded the world's first fully-accredited graduate program emphasizing the Functional Medicine approach to pathophysiology-assessment-treatment integration:

    • Books: Integrative Orthopedics (2005, 2007, 2012), Integrative Rheumatology (2007), Musculoskeletal Pain—Expanded Clinical Strategies (continuing medical education [CME] peer-reviewed monograph published by the Institute for Functional Medicine in 2008), Integrative Medicine and Functional Medicine for Hypertension (2011), Integrative Chiropractic Management of High Blood Pressure and Chronic Hypertension (2010, 2011), Integrative Orthopedics Third Edition (2012), Migraine Headaches, Hypothyroidism, and Fibromyalgia (2012), Chiropractic and Naturopathic Mastery of Clinical Disorders (2009), Functional Immunology and Nutritional Immunomodulation (2012), Fibromyalgia in a Nutshell (2012), Integrative Rheumatology, Nutritional Immunomodulation, and Functional Inflammology (2013).

    • More than 100 articles and letters: JAMA—Journal of the American Medical Association, BMJ—British Medical Journal, The Lancet.com, JAOA—Journal of the American Osteopathic Association, Annals of Pharmacotherapy, Journal of Clinical Endocrinology and Metabolism, Alternative Therapies in Health and Medicine, Nutritional Perspectives, Journal of Manipulative and Physiological Therapeutics, The Original Internist, Integrative Medicine, Holistic Primary Care, Nutritional Wellness, Dynamic Chiropractic, Evidence-based Complementary and Alternative Medicine, and Arthritis & Rheumatism: Official Journal of the American College of Rheumatology.

Loren Cordain, Ph.D.
  • Biographical sketch: Dr. Loren Cordain is the world’s foremost authority on the evolutionary basis of diet and disease. Featured on Dateline NBC, the front page of the Wall Street Journal, and the New York Times, Dr. Cordain is widely acknowledged as one of the world’s leading experts on the natural human diet of our Stone Age ancestors. He is the author of more than 100 peer-reviewed scientific articles and abstracts, and his research into the health benefits of Stone Age Diets for contemporary people has appeared in the world’s top scientific journals including the American Journal of Clinical Nutrition, the British Journal of Nutrition, and the European Journal of Clinical Nutrition, among others. Dr. Cordain’s popular book, The Paleo Diet, has been widely acclaimed in both the scientific and lay communities and was fully revised in 2010. His next book, The Paleo Diet for Athletes, published in October 2005, discusses how the Paleo Diet can be modified for the high performance endurance athlete and lead to improved health and performance. His next book, The Dietary Cure for Acne, is available in paperback and as an instant download ebook. The Paleo Diet Cookbook was published in 2010 and became an instant bestseller. His most recent book, The Paleo Answer, was released in December 2011, and represents a sequel to The Revised Paleo Diet. Dr. Cordain is the recipient of the Scholarly Excellence award at Colorado State University for his contributions into understanding optimal human nutrition.
    • Book: The Paleo Diet -- international best-seller.
Professor Emeritus Garth L. Nicolson, Ph.D.
  • Biographical sketch: Professor Garth L. Nicolson is the President, Chief Scientific Officer and Research Professor at the Institute for Molecular Medicine in Huntington Beach, California. He is also a Conjoint Professor at the University of Newcastle (Australia). He was formally the David Bruton Jr. Chair in Cancer Research and Professor and Chairman of the Department of Tumor Biology at the University of Texas M. D. Anderson Cancer Center in Houston, and he was Professor of Internal Medicine and Professor of Pathology and Laboratory Medicine at the University of Texas Medical School at Houston. He was also Professor of Comparative Pathology at Texas A & M University. Professor Nicolson has published over 600 medical and scientific papers, including editing 19 books, and he has served on the Editorial Boards of 30 medical and scientific journals and was a Senior Editor of four of these. Professor Nicolson has won many awards, such as the Burroughs Wellcome Medal of the Royal Society of Medicine (United Kingdom), Stephen Paget Award of the Metastasis Research Society, the U. S. National Cancer Institute Outstanding Investigator Award, and the Innovative Medicine Award of Canada. He is also a Colonel (Honorary) of the U. S. Army Special Forces and a U. S. Navy SEAL (Honorary) for his work on Armed Forces and veterans’ illnesses.
Lynda Frassetto, M.D.
  • Biographical sketch: Lynda Frassetto, MD, is a Professor of Medicine in the Division of Nephrology at the University of California, San Francisco (USCF). She grew up in the greater New York metropolitan area and attended college and medical school in Connecticut.  She trained as a nephrologist at UCSF and was in private practice in San Francisco before returning to UCSF to start her research career with Drs. Anthony Sebastian and R. Curtis Morris Jr. Over the last 15 years, the group has published papers on regulation of acid base balance in healthy and aging people and dietary influences on acid-base balance in healthy people and those with diabetes. Dr. Frassetto also collaborates with Dr. Leslie Z Benet, past chair of the Department of Biopharmaceutical Sciences at UCSF. Dr. Benet has pioneered a novel model predicting drug interactions in vivo, depending on the degree of in vitro membrane transporter and intracellular metabolizing enzyme interactions with a specific drug, xenobiotic or toxin. These predictions are then tested in clinical trials in healthy people and those with kidney disease, diabetes or HIV before and after transplantation. In addition to research, Dr. Frassetto is presently the director of the adult Clinical Research Center at the Parnassus Campus in UCSF’s Clinical and Translational Science Institute, supervises inpatient and outpatient care at three of the University’s hospital campuses, and for the last several years has been participating in programs that teach UC students and faculty better communication and behavioral stress modification techniques.
James OKeefe M.D.
  • Biographical sketch: Dr. James O'Keefe Jr., MD (born June 8, 1956) is an American author and cardiologist best known for his studies in the field of cardiovascular medicine, diet and exercise. O’Keefe is the co-author of the best selling consumer health books, The Forever Young Diet & Lifestyle and Let Me Tell You a Story. He is currently a professor of medicine at the University of Missouri–Kansas City and Director of Prentice Cardiology at St. Luke's Cardiovascular Consultants, a large cardiology practice based in Kansas City. In 1982, he graduated with his MD from Baylor College of Medicine. He then completed his medical residency as well as a cardiovascular fellowship at the Mayo Graduate School of Medicine in Rochester, Minnesota. He did an advanced fourth year cardiovascular fellowship in nuclear cardiac imagery and interventional cardiology. O’Keefe is the director of the Preventive Cardiology Fellowship Program at the Saint Luke’s Mid America Heart Institute. At the Mid America Heart Institute, he is actively involved with patient care, clinical research as well as non-invasive cardiology practices. He has been board-certified in cardiology, nuclear cardiology, pacing, lipids, cardiac CT imaging, and internal medicine.He has been named to many top doctors lists, both regionally and nationally, including USA Today's Most Influential American Physicians, Ingram’s Business Magazine, Kansas City Family Magazine, and Consumer Guide to Top Doctors In 1989, he became a Professor of Medicine at the University of Missouri in Kansas City. Dr. O’Keefe is also a fellow of the American College of Cardiology and the American Heart Association Council of Clinical Cardiology. Dr. O’Keefe has contributed over 250 articles to medical literature.  These include his numerous studies on vitamin D, omega-3, diet, exercise, and alcohol. He has been the lead author of four best-selling books, including, The Forever Young Diet & Lifestyle, Dyslipidemia Essentials, Diabetes Essentials, and the Complete Guide to ECGs. He has been a contributor to chapters in eight other books.
    • Books: The Forever Young Diet & Lifestyle and Let Me Tell You a Story.
Michael J. Gonzalez M.S., M.H.S.N., D.Sc., Ph.D., F.A.C.N.
  • Biographical sketch: Dr. Michael J. Gonzalez is Professor at the Nutrition Program, School of Public Health in the Medical Sciences Campus, University of Puerto Rico. He earned a Bachelor Degree in Biology and Chemistry (Catholic University), a Masters in Cellular Biology and Biophysics (Nova University), and another Masters in Nutrition and Public Health (University of P.R.). He has a Doctorate in Nutritional Medicine (John F. Kennedy University). He also has a Doctorate in Health Sciences (Lafayette University), and another Doctorate in Nutritional Biochemistry and Cancer Biology (Michigan State University). He completed a Post-Doctoral Fellowship in Geriatrics at the School of Medicine, University of Puerto Rico. Dr. Gonzalez is a Fellow of the American College of Nutrition, and has authored over 150 scientific publications. He has serve as a member on several scientific journal Editorial Boards, such as Biomedicina, the Journal of Orthomolecular Medicine, and Alternative Medicine Reviews. As a consultant for several companies, he has been responsible for designing formulations of nutritional supplements and pharmaceutical products. He has been a consultant for The Center for the Improvement of Human Functioning (now Riordan Clinic), in Wichita, Kansas. He has obtained several research awards for his work on Nutrition and Cancer. He is currently Co- Director of RECNAC II project, and Research Director of the InBioMed Project Initiative. Dr. Gonzalez also serves as a nutrition consultant to the Puerto Rican Basketball National Team and is part of the Medical Commission of the Puerto Rican Basketball Federation. Doctor González and Dr. Jorge Miranda-Massari, founders of InBioMed, are leaders in the development of non-toxic chemotherapy treatments for cancer. The findings of their work with Intravenous Vitamin C as an anti-cancer agent, published in 2002, were confirmed by the NIH in 2005. They published the first Phase-I clinical study utilizing Intravenous Vitamin C for treatment of terminal cancer patients in 2005, and also published in 2005 the most comprehensive review on Vitamin C and Cancer, as a follow-up on the work of two times Nobel Laureate, Dr. Linus C. Pauling. They have brought many new concepts into the field, such as the Bioenergetic theory of carcinogenesis, the systemic saturation phenomenon of intravenous vitamin C, the metabolic correction concept for disease treatment and prevention.
    • Book: Drs Gonzalez, Miranda-Massari, Saul’s. I Have Cancer What Should I Do: The Orthomolecular Guide to Cancer Management provides evidence-based recommendations for an integrative approach for those dealing with cancer and seeking to improve quality of life and survival.
    • 2012 landmark publication: Gonzalez MJ, et al. The bio-energetic theory of carcinogenesis. Med Hypotheses. 2012 Oct;79(4):433-9 The altered energy metabolism of tumor cells provides a viable target for a non toxic chemotherapeutic approach. An increased glucose consumption rate has been observed in malignant cells. Warburg (Nobel Laureate in medicine) postulated that the respiratory process of malignant cells was impaired and that the transformation of a normal cell to malignant was due to defects in the aerobic respiratory pathways. Szent-Györgyi (Nobel Laureate in medicine) also viewed cancer as originating from insufficient availability of oxygen. Oxygen by itself has an inhibitory action on malignant cell proliferation by interfering with anaerobic respiration (fermentation and lactic acid production). Interestingly, during cell differentiation (where cell energy level is high) there is an increased cellular production of oxidants that appear to provide one type of physiological stimulation for changes in gene expression that may lead to a terminal differentiated state. The failure to maintain high ATP production (high cell energy levels) may be a consequence of inactivation of key enzymes, especially those related to the Krebs cycle and the electron transport system. A distorted mitochondrial function (transmembrane potential) may result. This aspect could be suggestive of an important mitochondrial involvement in the carcinogenic process in addition to presenting it as a possible therapeutic target for cancer. Intermediate metabolic correction of the mitochondria is postulated as a possible non-toxic therapeutic approach for cancer.



Deanna Minich Ph.D., F.A.C.N., C.N.S.
  • Biographical sketch: Dr. Minich has a unique approach to clinical medicine based in a combination of physiology and psychology. She has trained in functional medicine for the past decade with the “father of functional medicine,” Dr. Jeffrey Bland, as her mentor, and has served on the Nutrition Advisory Board for the Institute of Functional Medicine. Her academic background is in nutritional science, including a Master’s Degree in Human Nutrition and Dietetics from the University of Illinois at Chicago (1995), and a Ph.D. in Medical Sciences (Nutrition) from the University of Groningen in The Netherlands (1999). In conjunction with her academic degrees and extensive teaching experience at the university level, she is both a Fellow (F.A.C.N.) and a Certified Nutrition Specialist (C.N.S.) through the American College of Nutrition and has received education in functional medicine through the Institute of Functional Medicine. Dr. Minich has over ten years of experience working in both the food and dietary supplement industries with her last position as Vice President of Scientific Affairs at Metagenics, Inc., in which she was responsible for global product launches in addition to serving as a teaching clinician for international audiences of healthcare practitioners. She currently leads educational outreach as Vice President of Education at the Personalized Lifestyle Medicine Institute, which involves coordination of cutting-edge information and collaboration with opinion leaders in the personalized lifestyle medicine field, along with her role as adjunct faculty at the University of Western States, Bastyr University, Institute for Functional Medicine, and the Maryland University of Integrative Health. She is the author of five books on nutrition, wellness, and psychology, and is passionate in helping others to live well using therapeutic lifestyle changes.
    • Books: Essential Fatty Acid Absorption and Metabolism (1999); Chakra Foods for Optimum Health: A Guide to the Foods that can Improve Your Energy, Inspire Creative Changes, Open Your Heart, and Heal Body, Mind, and Spirit (Conari Press, 2009); An A-Z Guide to Food Additives (Conari Press, 2009); Quantum Supplements: A Total Health and Wellness Makeover with Vitamins, Minerals, and Herbs (Conari Press, 2010); The Complete Handbook of Quantum Healing: An A-Z Self-Healing Guide for Over 100 Common Ailments (Conari Press, 2011).
    • More than 20 scientific publications: Journal of Lipid Research; American Journal of Clinical Research; Nutrition Reviews; Journal of Clinical Lipidology; Biochimica Biophysica Acta; Gastroenterology; American Journal of Physiology - Gastrointestinal and Liver Physiology; Pediatric Research; Canadian Journal of Physiology and Pharmacology; Metabolic Syndrome and Related Disorders; Journal of Bone and Mineral Metabolism; Journal of Medicinal Food.

Decker Weiss N.M.D., F.A.S.A. (Fellow of the American Society of Angiology)

  • Biographical sketch: Dr. Decker Weiss is the first Naturopathic Physician to complete an internship, residency, and fellowship in a conventional medical system. Dr. Weiss trained in the Columbia Hospital System (AZ), the Arizona Heart Hospital, and the prestigious Arizona Heart Institute. Dr Weiss served on the staff of the Arizona Heart Hospital for over 10 years. Dr. Weiss is the first and only Naturopathic Physician to hold the credential of “Cardiologist” as a fellow of the American Society of Angiology. Dr. Weiss is the Author of “The Weiss Method, A Better Heart Better Life”, and travels the world training physicians and pharmacists on how to reverse heart disease naturally and reduce or eliminate the need for medications. Dr. Weiss has brought Naturopathic medicine to the world including Haiti and Tibet.
David Haase M.D.
  • Biographical sketch: Dr. Haase graduated from Calvin College (BS Biology), Vanderbilt University School of Medicine (MD) subsequently training and practicing at the Mayo Clinic becoming board certified in both Family and Integrative Holistic Medicine. He is the founder of the MaxWell Clinic for Proactive Medicine, CMO of the LifeStrive Group and CMO of Evoke Neuroscience. He holds certifications in Health Coaching, Nutrition, and Neurofeedback. Dr. Haase is faculty for the University of South Florida Medical School’s Master’s program in Nutritional and Metabolic Medicine and for Western States University’s Master’s program for Functional and Nutritional Medicine with the area of emphasis for each being Functional Neurophysiology. He is a reviewer for the Textbook of Functional Medicine and a reviewer for Alternative Medicine Reviews. Dr. Haase is a co-founder of the non-profit "TheFoodInitiative.org" where high-school youth learn to live health-response-able and world-response-able lives via a curriculum of small-group learning, organic gardening, and community service.

Kenneth Cintron M.D.
  • Biographical sketch: Dr. Cintron is an active Fellow of the American Academy of Orthopedic Surgeons. He graduated from the University of Puerto Rico School of Medicine in 1990 and completed his training in Orthopaedic Surgery Residency in 1995. He fulfilled a Foot and Ankle Surgery Fellowship at Emory University in Atlanta, Georgia in 1996. Dr. Cintron is Board Certified in Anti-Aging, Preventative, Regenerative and Functional Medicine and an Advanced Fellow of the American Academy of Anti-Aging Medicine. As a former owner an operator of BodylogicMD of Puerto Rico he dedicated his practice to helping women and men overcome health challenges associated with aging, using bioidentical hormone replacement therapy (BHRT) integrated with customized nutrition and fitness programs. He is author and co-author of several published articles related to both Orthopaedic Surgery and Integrative Medicine. During his career he has worked as Team Physician of professional basketball, baseball and volleyball teams as well as in Central American and Panamerican Games and 1996 Olympics. He is past President of the Puerto Rico Orthopaedic State Society and former member of the Board Of Councilors of the American Academy of Orthopaedic Surgeons.
Matthew Hirschey, Ph.D.
  • Biographical sketch: Dr Hirschey's laboratory at Duke University explores different aspects of mitochondrial function, a crucial sub-cellular organelle that is gaining increasing recognition as a regulator of human health. Mitochondrial dysfunction is correlated with several disease states. However, mitochondria perform several functions, including synthesis, degradation, fission/fusion, signaling and ATP production. Thus, before we can understand how mitochondrial dysfunction contributes to disease, we need to better understand mitochondrial function. The overall objective of the Hirschey Lab is to better understand the interaction between mitochondrial genes and function, to identify novel pathways that are dysfunctional in human disease, and to identify new targets which could be exploited for disease therapy.
  • Select Recent Publications:
    • DB Lombard, FW Alt, HL Cheng, J Bunkenborg, RS Streeper, R Mostoslavsky, J Kim, G Yancopoulos, D Valenzuela, A Murphy, Y Yang, Y Chen, MD Hirschey, RT Bronson, M Haigis, LP Guarente, RV Farese Jr, S Weisssman, E Verdin, B Schwer. Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation. Mol. Cell. Biol. (2007) 27: 8807-8814
    • MD Hirschey*, T Shimazu*, J-Y Huang*, E Verdin, Chapter 8: acetylation of mitochondrial proteins. Meth. Enzymol. (2009) 457: 137-147
    • MD Hirschey, T Shimazu, E Goetzman, E Jing, B Schwer, DB Lombard, CA Grueter, C Harris, S Biddinger, OR Ilkayeva, RD Stevens, Y Li, AK Saha, NB Ruderman, JR Bain, CB Newgard, RV Farese Jr., FW Alt, CR Kahn, and E Verdin. SIRT3 regulates mitochondrial fatty acid oxidation via reversible enzyme deacetylation. Nature (2010) 464: 121-125
    • J-Y Huang*, MD Hirschey*, T Shimazu*, LT Ho, E Verdin. Mitochondrial Sirtuins. Biochim. Biophys. Acta. (2010) 1804: 1645-1651
    • T Shimazu*, J-Y Huang*, MD Hirschey*, LT Ho, E Verdin Acetate metabolism and aging: an emerging connection. Mech. Aging and Develop. (2010) 131: 511-516
    • E Verdin, MD Hirschey, LWS Finley, MC Haigis. Sirtuin regulation of mitochondria - energy production, apoptosis, and signaling. Trends Biochem. Sci. (2010) 35: 669-675
    • T Shimazu*, MD Hirschey*, L Ha, K Dittenhafer, B Schwer, DB Lombard, Y Li, J Bunkenborg, JS Andersen, FW Alt, JM Denu, MP Jacobson, and E Verdin. SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2, Increases its Enzymatic Activity and Regulates Ketone Body Production. Cell Metab. (2010) 12: 654-661
    • X Qiu*, K Brown*, MD Hirschey, E Verdin and D Chen. Calorie Restriction Reduces Oxidative Stress by SIRT3-mediated SOD2 Activation. Cell Metab. (2010) 12: 662-667
    • MD Hirschey*, T Shimazu*, JA Capra*, KS Pollard, and E Verdin. SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2. Aging (2011) 3:1-8
    • MD Hirschey, T Shimazu, E Jing, CA Grueter, AM Collins, B Aouizerat, A Stancáková, E Goetzman, MM Lam, B Schwer, RD Stevens, MJ Muehlbauer, S Kakar, NM Bass, J Kuusisto, M Laakso, FW Alt, CB Newgard, RV Farese Jr., CR Kahn and E Verdin. SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerates the Development of the Metabolic Syndrome. Mol. Cell (2011) in press

Thomas O’Bryan, DC, CCN, DABCN
  • Biographical sketch: Dr. Thomas O'Bryan is an internationally recognized speaker and workshop leader specializing in Non-Celiac Gluten Sensitivity and Celiac Disease. He is a ‘Sherlock Holmes’, a clinician par excellence in treating chronic disease and metabolic disorders from a Functional Medicine perspective. He holds teaching Faculty positions with the Institute for Functional Medicine, the Institute for Integrative Medicine and the National University of Health Sciences. Dr. O’Bryan is always one of the most respected, highly-appreciated speakers at many conferences. Dr. O'Bryan's passion is in teaching the many manifestations of Non-Celiac Gluten Sensitivity and Celiac Disease as they occur inside and outside of the intestines.
Pedro Carrera Bastos M.A., M.S., Ph.D. candidate in Medical Sciences at Lund University, Sweden
  • Biographical sketch: Pedro Bastos is a Portuguese Nutrition researcher and PhD candidate in Medical Sciences, holding an MSc in Human Nutrition and three Post-graduate Diplomas (Clinical Nutrition; Functional Nutrition and Orthomolecular Medicine; Health & Exercise Science). He lectures extensively to health professionals on topics related to Nutrition across Europe, USA and Latin America and has authored and co-authored 12 scientific papers. Best known for being an expert in milk and milk-associated immune dysfunction and allergy.
    • Recent publications: Coauthor of scientific paper "The Western Diet and Lifestyle and Diseases of Civilization", which is already the most viewed paper of Dove Press: http://www.dovepress.com/getfile.php?fileID=9163
    • Melnik BC, John SM, Carrera-Bastos P, Cordain L. The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer. Nutr Metab (Lond). 2012 Aug 14;9(1):74 http://www.nutritionandmetabolism.com/content/pdf/1743-7075-9-74.pdf
    • Ramsden CE, Faurot KR, Carrera-Bastos P, Cordain L, De Lorgeril M, Sperling LS. Dietary fat quality and coronary heart disease prevention: a unified theory based on evolutionary, historical, global, and modern perspectives. Curr Treat Options Cardiovasc Med. 2009 Aug;11(4):289-301


Maelan Fontes M.S., Ph.D. candidate in Medical Sciences at Lund University, Sweden
  • Biographical sketch: Physical Therapist, Master in Science in Human Nutrition and Food Quality, PhD candidate in Medical Sciences, Researcher at the Center for Primary Health Care Research, Lund University, Sweden. Lecturer in several postgraduate courses in Spain and Portugal, Author of peer-reviewed papers on evolutionary nutrition. Focused on Food and Western Disease from an evolutionary perspective.







International Conference/College of Human Nutrition and Functional Medicine

   1.347.620.0262    https://vimeo.com/ichnfm 




Interested in being a Vendor/Exhibitor?